Palladium glutathione, N-acetylcysteine, D-penicillamine conjugation chemistry

The metalloelement Palladium has a number of potential Pharmaco-clinical advantages. Palladium compounds have antiviral, antibacterial, neuroprotective and antitumor properties. However studies have also indicated some mild to serious toxic effects of Palladium metalloelements. Biothiols are important antioxidants that provide protection against metals toxicity. The interaction of metalloelements with biothiols can provide valuable information about the level of toxicity of the metalloelements and about the protective role of biothiols thereof. In this piece of work the effect of salt and complexes of Palladium on the status of different thiols [GSH, NAC, and D-Pen] in aqueous medium, were examined, The thiol quantification was carried out using Elman's method through UV-visible spectrophotometry and 1 HNMR. Results of the study performed in aqueous medium showed that level of different thiols depleted after the addition of the inorganic salts and organic complexes of Palladium. The mechanism of interaction of Palladium with thiols was examined using H-NMR. The results indicate that the depletion in the level of thiols may be due to 1:1 or 1:2 conjugation of Palladium with thiols. These conjugation reactions further suggest that the Palladium have xenobiotic nature causing oxidative stress and thiols play their role in detoxification and biotransformation of these metalloelements

Frequency of complete heart block after surgical closure of perimembranous ventricular septal defect

Objective: to find the frequency of complete heart block [CHB] in patients undergoing surgical perimembranous Ventricular septal defect [VSD] closure

Methodology: this was a Descriptive cross sectional study performed in Cardiovascular Department Lady Reading Hospital Peshawar. Data was collected from 28 January 2013 to 28 July 2013 with sample size of 103.Sampling technique was non probability consecutive. All patients with perimembranous ventricular septal defect, aged 5 years to 25 years with any gender were included in the study

Results:-mean age was 12.63 years +/- 6.63. Patients were divided in four categories according to their age. Over all complete heart block in the perimembranous ventricular septal defect after surgical closure was 10[9.71%]. Age wise distribution of complete heart block shows that majority of the complete heart block 6[12.8%] were found in age less than or equal to 10 years

Conclusion:-VSD closure is less often associated with CHB but there should be arrangements for pace maker to timely pace the patient in case of any emergency

De vega's tricuspid annuloplasty for severe tricuspid regurgitation - early and midterm follow up

To assess early and midterm outcome of De Vega's Repair of Tricuspid Valve in Severe Tricuspid Regurgitation [TR]. This was a prospective observational study conducted from January 2007 to June 2011, at Cardiovascular department PGMI, Lady Reading Hospital Peshawar. De Vega's surgical repair of tricuspid valve was done in severe tricuspid regurgitation patients with mitral valve replacement [MVR] or with double valve replacement [DVR=MVR+ AVR [Aortic valve replacement]]. Pre operative and post operative early [with in 1month] and midterm [at 6 month] follow up data was collected and analyzed on the basis of New York Heart Association [NYHA] functional status and echocardiographic finding. The outcome of De Vega's repair was assessed. Total study population was 160, with age ranging from 14-52 years [mean age 21 years]. Out of these 160 patients 89 [55.60%] patients were female and 71 [44.40%] were male. Preoperative diagnosis of 118 patients was related to pure mitral valve disease, and 42 cases were having aortic valve disease along with mitral disease. All patients had severe TR. Patients who were free from TR in MVR group were 81.3% and 75.0% patient were TR free in DVR group at 6 months follow up and the repair was intact on echocardiography. De Vega's repair in Severe TR is a safe and economical procedure in our setup

Role of angiotensin converting enzyme inhibitor [captopril] in proteinuria, glomerular filtration rate and lipid profile in NIDDM patients

Clinical trial has shown the beneficial effects of captopril in delaying the progression of diabetic renal disease. We performed an analysis to determine in efficacy of captopril in slowing the progression of renal disease over a broad range of functional renal and extra renal impairment. Treatment of individuals with microscopic and macroscopic proteinuria in NIDDM patients with preexisting hypertension and hyperlipidemia by captopril delays, inhibit or even revert the disease